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PUBLICATIONS

2021 - PRESENT

  1. Buzzi B, Koseli E, Alkhlaif Y, Parker A, Mustafa MA, Lichtman AH, Buczynski MW, Damaj MI. Differential roles of diacylglycerol lipase (DAGL) enzymes in nicotine withdrawal. (2023) Brain Res 1817, 148483.

  2. Chen I, Murdaugh LB, Miliano C, Gregus AM, Buczynski MW. NAPE-PLD regulates specific baseline affective behaviors but is dispensable for inflammatory hyperalgesia. (2023), Neurobiol Pain, doi: 10.1016/j.ynpai.2023.100135

  3. Bustin KA, Shishikura K, Chen I, Lin Z, Zongtao L, McKnight N, Chang Y, Wang X, Li JJ, Arellano E, Pei L, Morton PD, Gregus AM#, Buczynski MW#, Matthews ML#. Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception. (2023) Mol Cell Neurosci, 125, 103842.

  4. Navia-Pelaez JM, Borges Paes Lemes J, Gonzalez L, Delay L, Dos Santos Aggum Capettini L, Lu JW, Gonçalves Dos Santos G, Gregus AM, Dougherty PM, Yaksh TL, Miller YI. AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons. (2023), Pain 164, e274-e285.

  5. Laque A, Wagner G, Matzeu A, De Ness G, Kerr T, Carroll A, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou T, Zorrilla E, Martin-Fardon R, Koya E, Ritter R, Weiss F, Suto N. Linking drug and food addiction via compulsive appetite. (2022) Br. J. Pharmacol. 179, 2589-2609.

  6. Gregus AM, Levine IS, Eddinger KA, Yaksh TL, Buczynski MW. Sex Differences in Neuroimmune Mechanisms of Pain. (2021), Pain 162, 2186-2200.

  7. Matikainen-Ankey BA, Earnest T, Ali M, Casey E, Wang JG, Sutton AK, Legaria AA, Barclay KM, Murdaugh LB, Norris MR, Chang YH, Nguyen KP, Lin E, Reichenbach A, Clarke RE, Stark R, Conway SM, Carvhalo F, Al-Hasani R, McCall JG, Creed MC, Cazares V, Buczynski MW, Krashes MJ, Andrews ZB, Kravitz AV. An open-source device for measuring food intake and operant behavior in rodents. (2021), eLife, doi: 10.7554/eLife.66173

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2016-2020

  1. Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat Chem Biol 16, 667-675. 

  2. Agoglia AE, Zhu M, Ying R, Sidhu H, Natividad LA, Wolfe SA, Buczynski MW, Contet C, Parsons LH, Roberto M, Herman MA. Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure. (2020) eNeuro, 10.1523/ENEURO.0420-19.2020

  3. Gregus AM and Buczynski MW. Druggable Targets in Endocannabinoid Signaling. (2020) Adv Exp Med Biol 1274, 177-201.  

  4. Miliano C, Scott ER, Murdaugh LB, Gnatowski ER, Faunce CL, Anderson MS, Reyes MM, Gregus AM, Buczynski MW. Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems. (2020) J Neurosci Methods, 10.1016/j.jneumeth.2019.108458

  5. Natividad LA#, Buczynski MW#, McClatchy DB, Yates JR 3rd. From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction. (2018) Proteomes, 10.3390/proteomes6040050. 

  6. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. (2018) PAIN 159, 2620-2629.

  7. De Luca MA, Buczynski MW, Di Chiara G. Loren Parsons' contribution to addiction neurobiology. (2018) Addict Biol, 10.1111/adb.12642.

  8. Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. (2018) Neuropsychopharmacology, 10.1038/s41386-018-0055-3.

  9. Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis IY, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. (2017) Addict Biol, 10.1111/adb.12568.

  10. Irimia C, Buczynski MW, Natividad LA, Laredo SA, Avalos N, Parsons LH. Dysregulated glycine signaling contributes to increased impulsivity during protracted alcohol abstinence. (2017), J Neurosci 37,1853-61.

  11. Natividad LA, Buczynski MW, Herman MA, Kirson D, Oleata CS, Irimia C, Polis I, Ciccocioppo R, Roberto M, Parsons LH. Constitutive Increases in Corticotropin Releasing Factor and Fatty Acid Amide Hydrolase Drive an Anxious Phenotype. (2017) Biol Psychiatry 82, 500-10.

  12. Buczynski MW#, Herman MA#, Hsu KL#, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH. Chronic nicotine exposure diminishes inhibitory control of VTA DA neurons through enhanced diacylglycerol lipase-mediated signaling. (2016), PNAS 113, 1086-91.

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2011-2015

  1. Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. (2013) PNAS 110, 13961, E2518-27.

  2. Niphakis MJ, Cognetta AB, Chang JW, Buczynski MW, Byrne F, Burston JJ, Chapman V, Cravatt BF. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. (2013) ACS Chem Neurosci 4,1322-32.

  3. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. (2013) FASEB 27, 1939-49.

  4. Buczynski MW, Polis IY, Parsons LH. The volitional nature of nicotine exposure differentially alters anandamide and oleoylethanolamide levels in the ventral tegmental area. (2013) Neuropsychopharmacology 38, 574-84.

  5. Wright MJ, Angrish D, Aarde SM, Barlow DJ, Buczynski MW, Creehan KM, Vandewater SA, Parsons LH, Houseknecht KL, Dickerson TJ, Taffe MA. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats. (2012) PLoS One 7, e44852.

  6. Natividad LA, Buczynski MW, Parsons LH, Torres OV, O’Dell LE. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal. (2012) J Neurochem 123, 578-88.

  7. Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF. Highly selective inhibitors of monoacylglycerol lLipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. (2012) Chem Biol, 19, 579-88.

  8. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived Hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. (2012) PNAS 109, 6721-6.

  9. Dumlao DS#, Buczynski MW#, Norris PC, Harkewicz, Dennis EA. High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. (2011) Biochim Biophys Acta 1811, 724-36.

 

2006 - 2010

  1. Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glia TLR4 receptor-mediated nociception and production of prostaglandin E2 and TNF. (2010) Br J Pharmacol 160, 1754-64.

  2. Buczynski MW, Parsons LH. Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls. (2010) Br J Pharmacol 160, 423-42.

  3. Buczynski MW#, Svensson CI#, Dumlao DS, Fitzsimmons B, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh, TL, Dennis EA. Inflammatory hyperalgesia induces essential eicosanoid production in spinal cord. (2010) J Neurochem 114, 981-93.

  4. Gregus AM, Inra CN, Giordano TP 3rd, Costa AC, Rajadhyaksha AM, Inturrisi CE. Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5. (2010) Neuroscience 169, 475-87.

  5. Gregus AM, Tropea TF, Wang Y, Hauck SC, Costa AC, Rajadhyaksha AM, Inturrisi CE. Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. (2010) Neurosci Lett. 2010 468, 186-9.​

  6. Blaho VA, Buczynski MW, Dennis EA, Brown CR. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. (2009) J Immunol 183, 5644-53.

  7. Blaho VA#, Buczynski MW#, Brown CR, Dennis EA. Lipidomic analysis of eicosanoid dynamics during the development and resolution of Lyme disease-induced arthritis in mice. (2009) J Biol Chem 284, 21599-612.

  8. Buczynski MW, Dumlao DS, Dennis EA. An integrated omics analysis of eicosanoid biology. (2009) J Lipid Res 50, 1015-38.

  9. Bogulavsky JJ, Gregus AM, Kim PT, Costa AC, Rajadhyaksha AM, Inturrisi CE. Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance. (2009) J Pharmacol Exp Ther 328, 579-87.

  10. Jacobsen FE#, Buczynski MW#, Dennis EA, Cohen SM. A macrophage cell model for selective metalloprotein inhibitor design. (2008) ChemBioChem 9, 2087-95.

  11. Buczynski MW, Stephens DL, Bowers-Gentry RC, Grkovich A, Deems RA, Dennis EA. TLR and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. (2007) J. Biol. Chem. 282, 22834-47.

  12. Deems RA, Buczynski MW, Bowers-Gentry RC, Harkewicz R, Dennis EA. Detection and quantitation of eicosanoids via high performance liquid chromatography/electrospray ionization mass spectrometry.  (2007) Methods Enzymol 432, 59-82.

  13. Grkovich A, Johnson CA, Buczynski MW, Dennis EA. Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1 dependent. (2006), J Biol Chem 281, 32978-87.

  14. Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC Jr, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA. Purification and properties of Escherichia coli Kdo2-lipid A, a defined endotoxin that activates macrophages via TLR-4. (2006) J Lipid Res 47, 1097-1111.

 

       #These authors contributed equally to this work

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