NEUR 4914/5914 - Drug Development in Neuroscience
Spring 2020 (3 Credits)
Current approaches and pitfalls for developing therapeutics for treating disorders of the central nervous system (CNS). Theoretical issues and practical applications targeting identification, high-throughput screening, pharmacokinetics and pharmacodynamics, preclinical testing, clinical trials, and the FDA approval process. Ethical implications for drug development and testing.
Prerequisites: NEUR 3044 or NEUR 3914, or Graduate Standing (for 5914)
Introduction
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Syllabus and Course Outline
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History of CNS Drug Development
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Modern Drug Development Overview
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Challenges Targeting CNS
Preclinical
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Types of Potential Therapeutics
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Techniques used in Drug Development
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Target Identification
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High-Throughput Drug Screening
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Pharmacokinetics and Pharmacodynamics
Clinical
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FDA Approval Process
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Preclinical Drug Testing (Phase 0)
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Clinical Safety Testing (Phase 0-1)
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Clinical Trials for Efficacy (Phase 2-3)
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Postmarketing Surveillance (Phase 4)